Side Effects & SafetyWhen taken by mouth: Hyaluronic acid is LIKELY SAFE when used appropriately. Rarely, it may cause allergic reactions.
When applied to the skin: Hyaluronic acid is LIKELY SAFE when used appropriately. Rarely, it may cause allergic reactions.
When given as a shot: Hyaluronic acid is LIKELY SAFE when used appropriately. Hyaluronic acid can cause redness and soreness when injected into the joint.
When applied into the eye: Hyaluronic acid is LIKELY SAFE when used appropriately. Hyaluronic acid can increase eye pressure when injected into the eye. But this usually resolves within 48 to 72 hours.
Special Precautions & Warnings: Pregnancy: Hyaluronic acid is POSSIBLY SAFE when given by injection when pregnant. However, there isn''t enough reliable information to know if hyaluronic acid is safe to take by mouth or apply to the skin when breastfeeding. Stay on the safe side and avoid use.
Hardening of skin and connective tissue (scleroderma): Applying hyaluronic acid to the skin might make skin ulcers worse in people who have a condition called scleroderma. If you have scleroderma, don''Ippolito C, Porta F, Majorana A. Efficacy of a solution composed by verbascoside, polyvinylpyrrolidone (PVP) and sodium hyaluronate in the treatment of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2016;38(7):559-62. View abstract. Becker LC, Bergfeld WF, Belsito DV, et al. Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate. Int J Toxicol 2009;28(4 Suppl):5-67. View abstract. Bergstrand S, Ingstad HK, Møystad A, Bjørnland T. Long-term effectiveness of arthrocentesis with and without hyaluronic acid injection for treatment of temporomandibular joint osteoarthritis. J Oral Sci. 2019;61(1):82-88. View abstract. Bruyere O, Honvo G, Veronese N, et al. 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Increase of bone mineral density with sodium fluoride in patients with Crohn''t intend to refill right now.